Caspase-cleaved fragments of cytokeratin 18 in patients with chronic hepatitis B

EREN F., YILMAZ Y., Kose Ş., Ozdemir F. T., Yonal O., Kurt R., ...Daha Fazla

CLINICA CHIMICA ACTA, cilt.411, sa.23-24, ss.2029-2032, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 411 Sayı: 23-24
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.cca.2010.08.035
  • Dergi Adı: CLINICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2029-2032
  • Anahtar Kelimeler: Cytokeratin 18, Apoptosis, Chronic hepatitis B, Inactive carriers, EXTRACELLULAR CYTOKERATIN-18, DIAGNOSTIC-TESTS, SOLUBLE FORMS, LIVER-INJURY, APOPTOSIS, INFECTION
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Background: During hepatocyte apoptosis, intermediate filament protein cytokeratin 18 is cleaved by caspases at Asp396 which can be specifically detected by the monoclonal antibody M30 (M30-antigen). In this study, we sought to determine whether serum M30-antigen levels can serve as a useful biomarker of liver injury in the clinical spectrum of HBV infection.