Caspase-cleaved fragments of cytokeratin 18 in patients with chronic hepatitis B

EREN F., YILMAZ Y., Kose Ş., Ozdemir F. T., Yonal O., Kurt R., ...More

CLINICA CHIMICA ACTA, vol.411, no.23-24, pp.2029-2032, 2010 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 411 Issue: 23-24
  • Publication Date: 2010
  • Doi Number: 10.1016/j.cca.2010.08.035
  • Journal Name: CLINICA CHIMICA ACTA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2029-2032
  • Keywords: Cytokeratin 18, Apoptosis, Chronic hepatitis B, Inactive carriers
  • Dokuz Eylül University Affiliated: No

Abstract

Background: During hepatocyte apoptosis, intermediate filament protein cytokeratin 18 is cleaved by caspases at Asp396 which can be specifically detected by the monoclonal antibody M30 (M30-antigen). In this study, we sought to determine whether serum M30-antigen levels can serve as a useful biomarker of liver injury in the clinical spectrum of HBV infection.