Presenting with Isolated Hepatitis Caused by Congenital Rubella Infection Due to Maternal Rubella Vaccination

Korkmaz H. A., ARSLAN N., AYDIN A.

JOURNAL OF PEDIATRIC INFECTION, vol.9, no.1, pp.38-41, 2015 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.5152/ced.2013.1605
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.38-41
  • Keywords: Rubella vaccine, congenital rubella infection, hepatitis, VIRUS, IMMUNIZATION, RISK
  • Dokuz Eylül University Affiliated: Yes


Congenital rubella syndrome is a transplacental infection that may cause serious devastating damage in the fetus, including intrauterine growth retardation, cataracts, patent ductus arteriosus, hearing loss, microcephaly, thrombocytopenia, and hepatitis. Rubella vaccine is administered for preventing congenital rubella syndrome. It is suggested that patients must be screened for pregnancy before vaccination and should be informed regarding contraception for 3 months after vaccination. Herein, we presented a 1-month-old boy to whom rubella vaccine was administered. After performing multiple diagnostic studies to exclude other liver disorders, the patient, who had high liver enzymes, was diagnosed with congenital rubella infection by his mother's history and positive anti-rubella IgM. His liver enzymes returned to normal at 2 months of age of the follow-up period. Negative anti-rubella IgM was revealed at 6 months of age. As a result, when rubella vaccine is administered in pregnancy, high liver enzymes might occur without other congenital rubella syndrome signs in newborns. Infants who are borne by pregnant women with rubella vaccination should be monitored.