The effects of quinapril on plasma level of tissue inhibitor metalloproteinase 1, left ventricular hypertrophy and diastolic functions in hypertensive patients
Turkiye Klinikleri Cardiovascular Sciences, vol.22, no.3, pp.297-304, 2010 (Scopus)
- Publication Type: Article / Article
- Volume: 22 Issue: 3
- Publication Date: 2010
- Journal Name: Turkiye Klinikleri Cardiovascular Sciences
- Journal Indexes: Scopus
- Page Numbers: pp.297-304
- Keywords: Angiotensin-converting enzyme inhibitors, Doppler, Echocardiography, Hypertension, Hypertrophy, Left ventricular, Tissue inhibitor of metalloproteinase-1
- Dokuz Eylül University Affiliated: Yes
Abstract
Objective: Plasma level of tissue inhibitor metalloproteinase type-1 (TIMP-1) reflecting extends of extracellular fibrosis was found to be associated with left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD). We aimed to investigate the effect of quinapril therapy on TIMP-1 levels, LVH and LVDD in hypertensive patients. Material and Methods: A total of 30 hypertensive patients with LVH (14 male, mean age 64.3 years) were enrolled to this study. The initial daily dose of quinapril was 20 mg/day. The dose was uptitrated to 40 mg/d and hydrochlorothiazide was added if necessary. LV mass index (LVMI) was calculated and left ventricular diastolic parameters were evaluated by transthoracic echocardiography. Transmitral and tissue Doppler pulse wave velocities were measured and, E/A and Em/Am ratios were calculated. Systolic and diastolic blood pressures, LVMI, LV diastolic functions and plasma TIMP 1 levels were evaluated at baseline and six months after the therapy. Results: After quinapril therapy LVMI (p< 0.001), systolic (p< 0.001) and diastolic blood pressures (p< 0.001) and transmitral deceleration time (p= 0.017) significantly decreased, and septal Em/Am ratio increased (p= 0.003). Plasma TIMP-1 level was also significantly reduced after therapy (619.9 ± 108.1-485.6 ± 105.9 ng/dl; p< 0.001). There were no significant correlations between the ΔTIMP-1 levels and any of the other parameters including Δ systolic (r= 0.12; p= 0.51) and Δ diastolic (r= 0,10; p= 0.58) blood pressures changes, Δ deceleration time (p= 0.98), and Δ Em/Am ratio (p= 0.76). Conclusion: Quinapril therapy reduced TIMP-1 levels, independently from regression of LVH and reduction of blood pressures in hypertensive patients. Copyright © 2010 by Türkiye Klinikleri.