Akademik Veri Yönetim Sistemi
IZMIR DR BEHCET UZ COCUK HASTANESI DERGISI, cilt.3, sa.2, ss.77-86, 2013 (ESCI, TRDizin)
Atopic dermatitis is a common chronic inflammatory skin disease associated with cutaneous hyperreactivity to various environmental triggers. The aim of the treatment should be focused on suppression of chronic inflammation and control of acute exacerbations. Education of the patient is necessary to increase the disease perception and improve modification of the scratch control behaviour that will lead to a better skin care and improvement in the quality of life. Appropriate treatment is also necessary for the prevention of microbial colonization, invasive skin infections and further systemic complications. Basic therapy of atopic dermatitis should comprise optimal skin care with regular use of emollients, and avoidance from specific triggering factors. Topical treatment options like topical corticosteroids and calcineurin inhibitors are the milestones of the severe atopic dermatitis. The risk of adverse effects induced by topical corticosteroids could be reduced by proactive treatment modality and balancing risk/benefit ratio. Topical calcineurin inhibitors allow a steroid-free anti-inflammatory topical treatment with a safe application on sensitive skin areas. Further treatment options, on the basis of the disease severity, includes addition of multiple therapeutic agents in a stepwise approach. In severe cases of atopic dermatitis, systemic treatment options including oral steroids, immunosuppressant drugs, wet wrap and immunoglobulin G can be considered. Systemic antibiotic treatment is indicated for widespread secondary bacterial skin infections. The management of atopic dermatitis should be individualized according to the severity of the disease and patients' clinical conditions.