Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel

Babiloni C., Arakaki X., Azami H., Bennys K., Blinowska K., Bonanni L., ...More

ALZHEIMERS & DEMENTIA, vol.17, no.9, pp.1528-1553, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 17 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.1002/alz.12311
  • Journal Name: ALZHEIMERS & DEMENTIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, ASSIA, EMBASE, MEDLINE, Psycinfo
  • Page Numbers: pp.1528-1553
  • Keywords: Alzheimer&apos, s disease, biomarkers, clinical trials, dementia, electroencephalography (EEG), eyes&#8208, closed resting state condition, The Alzheimer&apos, s Association International Society to Advance Alzheimer&apos, s Research and Treatment (ISTAART), MILD COGNITIVE IMPAIRMENT, GRAPH-THEORETICAL ANALYSIS, CEREBRAL-BLOOD-FLOW, ELECTROENCEPHALOGRAPHIC ALPHA RHYTHMS, FREQUENCY-SPECIFIC CHANGES, TEST-RETEST RELIABILITY, QUANTITATIVE EEG, SPECTRAL-ANALYSIS, CORTICAL SOURCES, FUNCTIONAL CONNECTIVITY
  • Dokuz Eylül University Affiliated: Yes

Abstract

The Electrophysiology Professional Interest Area (EPIA) and Global Brain Consortium endorsed recommendations on candidate electroencephalography (EEG) measures for Alzheimer's disease (AD) clinical trials. The Panel reviewed the field literature. As most consistent findings, AD patients with mild cognitive impairment and dementia showed abnormalities in peak frequency, power, and "interrelatedness" at posterior alpha (8-12 Hz) and widespread delta (< 4 Hz) and theta (4-8 Hz) rhythms in relation to disease progression and interventions. The following consensus statements were subscribed: (1) Standardization of instructions to patients, resting state EEG (rsEEG) recording methods, and selection of artifact-free rsEEG periods are needed; (2) power density and "interrelatedness" rsEEG measures (e.g., directed transfer function, phase lag index, linear lagged connectivity, etc.) at delta, theta, and alpha frequency bands may be use for stratification of AD patients and monitoring of disease progression and intervention; and (3) international multisectoral initiatives are mandatory for regulatory purposes.