Arrhythmic Markers and Clozapine in Patients with Schizophrenia: Effect of 10 weeks Clozapine Treatment on Heart Rate Variability, Late Potentials and QT Dispersion

Tuemueklue M. N., ALPTEKİN K., Kirimli O., Aslan O., AKDEDE B. B., Badak Ö., ...More

KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, vol.18, no.3, pp.167-173, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 3
  • Publication Date: 2008
  • Journal Name: KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.167-173
  • Keywords: Schizophrenia, clozapine, heart rate variability, late potentials, QT dispersion, AUTONOMIC NERVOUS-SYSTEM, ANTIPSYCHOTIC-DRUGS, ATYPICAL ANTIPSYCHOTICS, SEX-DIFFERENCES, RATE DYNAMICS, SUDDEN-DEATH, RISK, OLANZAPINE, ABNORMALITIES
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Clozapine is a well-known atypical antipsychotic agent which is especially useful in patients with treatment-resislant schizophrenia, but there is still debate on its potential to cause arrhythmia and sudden death. To explore the effect of clozopine on arrhythmic markers in patients with schizophrenia, heart rate variability, QT dispersion and late potentials were measured before and after 10 weeks' treatment.