Factor I Autoantibodies in Patients with Atypical Hemolytic Uremic Syndrome: Disease-Associated or an Epiphenomenon?

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Kavanagh D., Pappworth I. Y., Anderson H., Hayes C. M., Moore I., Hunze E., ...More

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol.7, no.3, pp.417-426, 2012 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 7 Issue: 3
• Publication Date: 2012
• Doi Number: 10.2215/cjn.05750611
• Journal Name: CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.417-426
• Dokuz Eylül University Affiliated: No

Abstract

Background and objectives Atypical hemolytic uremic syndrome is a disease associated with mutations in the genes encoding the complement regulators factors H and I. In addition, factor H autoantibodies have been reported in similar to 10% of patients with atypical hemolytic uremic syndrome. This study searched for the presence of factor 1 autoantibodies in atypical hemolytic uremic syndrome.