Factor I Autoantibodies in Patients with Atypical Hemolytic Uremic Syndrome: Disease-Associated or an Epiphenomenon?

Kavanagh D., Pappworth I. Y., Anderson H., Hayes C. M., Moore I., Hunze E., ...More

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol.7, no.3, pp.417-426, 2012 (SCI-Expanded) identifier identifier identifier


Background and objectives Atypical hemolytic uremic syndrome is a disease associated with mutations in the genes encoding the complement regulators factors H and I. In addition, factor H autoantibodies have been reported in similar to 10% of patients with atypical hemolytic uremic syndrome. This study searched for the presence of factor 1 autoantibodies in atypical hemolytic uremic syndrome.