Evaluation of Depression, Anxiety and Health- Related Quality of Life in Patients with Hepatitis B Virus-Infection

Kiratli K., Dikici O., Kose Ş.

FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI, vol.28, no.2, pp.264-274, 2023 (ESCI) identifier identifier


Introduction: Chronic hepatitis B patients may experience many psychological and emotional symptoms. In our study, it was aimed to compare the anxiety, depression and quality of life scores of chronic hepatitis B patients and inactive HBV carriers and to examine the necessity of psychiatric evaluation and follow-up during the treatment of people with HBV infection. Materials and Methods: Patients followed up due to hepatitis B infection and a similar number of healthy individuals (total= 178 individuals) were included in the study. Sociodemographic information form, "Hospital Anxiety and Depression Scale", "Short Form-36" and "Liver Disease Symptom Index 2.0" were filled in for all subjects included in the study.Results: In terms of normal and abnormal anxiety scores, there was a difference between the three groups according to Hospital Anxiety and Depression Scale (p< 0.001). Physical function (p< 0.001), emotional role difficulty (p= 0.006), vitality (p= 0.003), mental health (p= 0.001) and general health (p< 0.001) scores was significantly lower in the chronic hepatitis B group compared to other groups. In carriers, according to the Liver Disease Symptom Index 2.0, all items except anxiety, depression and memory problems in the family were found below 50%. In the chronic hepatitis B group, except for jaundice, personality change, inadequacy in financial affairs, involuntary movements, change in time use and decrease in sexual interest, other items were found to be over 50%.Conclusion: Informing patients about the disease process continuously will reduce their anxiety and contribute to their adherence to treatment. Evaluation of the effects of chronic liver disease on quality of life will help us in better management of the disease.