Serum free light chain analysis in multiple myeloma and plasma cell dyscrasias

ÖZSAN G. H., Dispenzieri A.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY, cilt.7, sa.1, ss.65-73, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 7 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1586/eci.10.80
  • Dergi Adı: EXPERT REVIEW OF CLINICAL IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.65-73
  • Anahtar Kelimeler: free light chain, immunoglobulin, multiple myeloma, plasma cell disorders, INDEPENDENT RISK-FACTOR, MONOCLONAL GAMMOPATHY, UNDETERMINED SIGNIFICANCE, PROGNOSTIC VALUE, RATIO, PROGRESSION, URINE, TRANSPLANTATION, IMMUNOFIXATION, PERFORMANCE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

After the development of a reliable method to detect free light chains in serum, several investigations have been conducted to explore their importance in plasma cell dyscrasias (PCD). Detection of monoclonal proteins is very important in the diagnosis and management of PCD, which include a broad spectrum of diseases such as multiple myeloma and also benign, premalignant disorders like monoclonal gammopathy of undetermined significance. The aim of this article is to summarize the recent studies and to highlight the importance of free light chain analysis in the diagnosis of PCD, its prognostic value and role in the management of this group of diseases.