Mesangial C4d deposition is independently associated with poor renal survival in patients with primary focal segmental glomerulosclerosis


Heybeli C., Oktan M. A., Yildiz S., Unlu M., Celli A., SARIOĞLU S.

CLINICAL AND EXPERIMENTAL NEPHROLOGY, vol.23, no.5, pp.650-660, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 5
  • Publication Date: 2019
  • Doi Number: 10.1007/s10157-018-01688-0
  • Journal Name: CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.650-660
  • Keywords: Complement C4d, Focal segmental glomerulosclerosis, IgM, Mannan-binding lectin, COMPLEMENT PATHWAY, IGA NEPHROPATHY, LECTIN PATHWAY, C3
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background C4d deposition is defined as the footprint of immune injury and it is associated with unfavorable renal outcomes in patients with IgA nephropathy. We searched whether mesangial C4d deposition is associated with poor renal survival in patients with primary focal segmental glomerulosclerosis (FSGS).