Genetic diversity is a predictor of mortality in humans


Bihlmeyer N. A., Brody J. A., Smith A. V., Lunetta K. L., Nalls M., Smith J. A., ...More

BMC GENETICS, vol.15, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15
  • Publication Date: 2014
  • Doi Number: 10.1186/s12863-014-0159-7
  • Journal Name: BMC GENETICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Heterozygosity, Human, Survival, GWAS, FACIAL ATTRACTIVENESS, HETEROZYGOSITY, DISEASES, TRAITS, HEALTH
  • Dokuz Eylül University Affiliated: No

Abstract

Background: It has been well-established, both by population genetics theory and direct observation in many organisms, that increased genetic diversity provides a survival advantage. However, given the limitations of both sample size and genome-wide metrics, this hypothesis has not been comprehensively tested in human populations. Moreover, the presence of numerous segregating small effect alleles that influence traits that directly impact health directly raises the question as to whether global measures of genomic variation are themselves associated with human health and disease.