Metal levels and potential health risk assessment in muscle, liver, and gills of three fish species (Merluccius merluccius, Mullus barbatus, and Pagellus erythrinus) from the Edremit Bay were investigated in spring and autumn 2015. Metal concentrations (Hg, Cd, Pb, Cr, Cu, Zn, Mn, and Fe), metal pollution index, and bioaccumulation factors in P. erythrinus were observed to be generally higher than those in M. barbatus and M. merluccius. Tissue was the main factor that might be responsible from the variations of metals in fish species according to ANOVA and PCA. Hg concentrations in M. barbatus and P. erythrinus were greater than threshold limits defined by international authorities; however, no carcinogenic risks were found for Cd and Pb levels. According to the results, the bay has been negatively influenced by human activities, and further research on monitoring of the biota and sediments is recommended for Edremit Bay and similar coastal areas under human pressure.