Farelerde Yüksek Doz İsotretinoin Uygulamasının Yol Açtığı Kalp Dokusu Hasarına Karşı Silymarinin Olası Etkilerinin Araştırılması

KUMAŞ M., EŞREFOĞLU M., ÖZER Ö. F.

Bezmiâlem Science, vol.4, no.2, pp.43-50, 2016 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.14235/bs.2016.682
  • Journal Name: Bezmiâlem Science
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.43-50
  • Keywords: Isotretinoin, silymarin, heart, oxidative stress, apoptosis, histopathology, ACNE PATIENTS, CARBON-TETRACHLORIDE, RETINOIC ACID, GLUTATHIONE, ANTIOXIDANT, HEPATOTOXICITY, RATS
  • Dokuz Eylül University Affiliated: No

Abstract

Objective: We aimed to histopathologically and biochemically investigate the protective effects of silymarin (SLY) against cardiac injury induced by a high-dose isotretinoin (ISR) administration.