FREQUENCY OF PULMONARY HYPERTENSION IN ASYMPTOMATIC β-THALASSEMIA MAJOR PATIENTS AND THE ROLE OF PHYSIOLOGICAL PARAMETERS IN EVALUATION

Kiter G., Balci Y. I., Ates A., Hacioglu S., SARI İ.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.27, sa.8, ss.597-607, 2010 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 8
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3109/08880018.2010.503338
  • Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.597-607
  • Anahtar Kelimeler: epidemiology, pulmonary function test, pulmonary hypertension, thalassemia major
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

In this study, the authors aimed to evaluate the frequency of pulmonary hypertension (PHT) in asymptomatic thalassemia major (TM) patients, and to investigate the impact of pulmonary function test (PFT) and CO diffusion results on the evaluation of pulmonary hypertension. Data from 50 asymptomatic patients with TM over age 10 were evaluated. Pulmonary hypertension was diagnosed in 10 patients (20%). High tricuspid regurgitant jet velocity was found in 14% of adults and in 25% of children. Pulmonary function test including CO diffusion testing results were not different between the TM patients with or without pulmonary hypertension. In conclusion, PHT was frequent among TM patients even they were asymptomatic and although PFT results has shown lack of association, it should be investigated in larger population.