The effects of preoperative immunosuppressive therapy on ischemia and reperfusion (I/R) injury in healthy rats

Kilinc, Selcuk; Tan, Sedat; KOLATAN, HATİCE; Ruscuklu, Dane; Satici, Esra; Kemiksiz, Mehmet; Dalkilic, Lutfi; Erdogdu, Umut; Karaca, Cezmi

doi:10.1007/s11255-013-0548-2

The effects of preoperative immunosuppressive therapy on ischemia and reperfusion (I/R) injury in healthy rats

Kilinc S., Tan S., KOLATAN H. E., Ruscuklu D., Satici E., Kemiksiz M., ...More

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.46, no.2, pp.389-393, 2014 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 46 Issue: 2
Publication Date: 2014
Doi Number: 10.1007/s11255-013-0548-2
Journal Name: INTERNATIONAL UROLOGY AND NEPHROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.389-393
Keywords: Ischemia-reperfusion injury, Toll-like receptors, Rat model, TLR
Dokuz Eylül University Affiliated: Yes

Abstract

Purpose Warm-ischemia-induced injuries might be encountered during renal transplants from cadavers and healthy donors. Toll-like receptors (TLR) in ischemia-reperfusion (I/R) injury are one of the indicators of intracellular injury pathways. The intensity of ischemic injury is directly proportionate to high TLR levels. To minimize the I/R injury, we investigated TLR2 and TLR4 levels on rats, which were pretreated with tacrolimus (FK506) before I/R.