Akademik Veri Yönetim Sistemi
2025 SIRS Conference, Illinois, Amerika Birleşik Devletleri, 29 Mart - 02 Nisan 2025, ss.21, (Özet Bildiri)
Background: Anomalies in structural brain networks (connectomes) have been implicated in the pathophysiology of psychotic disorders. This study investigates changes in structural brain networks in youth experiencing first-episode psychosis.
Methods: This study included 32 individuals with first-episode psychosis and 26 healthy controls. Diffusion-weighted magnetic resonance imaging was employed, and whole-brain streamline counts were generated using MRtrix3. Following preprocessing, structural connectivity networks were constructed using the Schaefer parcellation with 400 non-overlapping cortical regions. Network analysis was conducted in MATLAB using the REST toolbox. Statistical analysis was performed with the Network-Based Statistics toolbox, employing permutation testing with family-wise error correction.
Results: Significant differences in structural connectivity were found between the first-episode psychosis group and healthy controls. The most prominent findings in the psychosis group, compared to controls, included reduced connectivity (p < 0.05) in the following regions: (I) within visual networks, (II) between visual and default mode networks, (III) between dorsal attention and somatomotor networks.
Discussion: While the visual network is not traditionally viewed as a primary contributor to psychosis pathophysiology, emerging evidence highlights abnormalities in the visual system in psychotic disorders. This growing body of evidence underscores the need for further research to elucidate the specific contributions of visual system dysfunction to the development of psychotic disorders.