Early and delayed thallium-201 scintigraphy in thyroid nodules: The relationship between early thallium-201 uptake and perfusion

Derebek E., Biberoglu S., Kut O., Yesil S., Saydam S., Yilmaz M., ...More

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, vol.23, no.5, pp.504-510, 1996 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 5
  • Publication Date: 1996
  • Doi Number: 10.1007/bf00833383
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.504-510
  • Keywords: thallium-201 -, thyroid nodules -, tumour perfusion, CLINICAL-EVALUATION, TL-201 UPTAKE, DIAGNOSIS, CANCER, MALIGNANCY, CHLORIDE, TC-99M, TUMORS, SCAN
  • Dokuz Eylül University Affiliated: No


Seventy-six patients with thyroid nodules were studied. Initially, 74 MBq of thallium-201 was injected. The thyroid gland was imaged 15 min (early) and 3 h (delayed) after the injection. Thereafter, 185 MBq technetium-99m pertechnetate was injected. Immediately after the injection, a 1-min perfusion image was acquired, followed by an image at 20 min. Increased early and delayed Tl-201 uptake compared with the contralateral thyroid tissue was adopted as the criterion for malignancy. Sensitivity, specificity and negative predictive values were found to be 85%, 64% and 78%, respectively, in operated patients, but these values were 86%, 87% and 95 %, respectively, in the whole group, including patients followed with fine-needle aspiration biopsy. With the purpose of investigating the relationship between perfusion and early Tl-201 uptake, both perfusion and early images were graded comparing nodular activity with contralateral thyroid activity. There was a poor correlation between perfusion and Tl-201 uptake. The correlation was even worse in hyperactive nodules. It is concluded that early and delayed Tl-201 imaging should not be used in the differential diagnosis of cold nodules and that early Tl-201 uptake seems to be more closely related to factors other than perfusion.