Subphthalocyanine as a fluorescence imaging agent for breast tumor

YURT ONARAN, FATMA; Ince, Mine; Er, Ozge; Soylu, Hale; OCAKOĞLU, KASIM; YILMAZ, OSMAN

doi:10.1016/j.pdpdt.2019.04.022

Subphthalocyanine as a fluorescence imaging agent for breast tumor

YURT ONARAN F., Ince M., Er O., Soylu H. M., OCAKOĞLU K., YILMAZ O.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, cilt.26, ss.361-365, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 26
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.pdpdt.2019.04.022
Dergi Adı: PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.361-365
Anahtar Kelimeler: Subphthalocyanine, Fluorescence imaging, Mammary tumor, Nude mice
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Tri-tert-butyl-carboxyl subphthalocyanine (SubPc) was synthesized and evaluated as a fluorescence agent. Fluorescence imaging for breast tumor in vivo was performed using nude mice as models. Results indicate high uptake in tumor at 20 h. Tumor-non tumor ratio was determined as 2.25. The imaging results demonstrate the potential of this fluorescence-imaging agent in the diagnosis of breast tumor. In the future, subphthalocyanine is also developing as a dual functional, which is fluorescence imaging and as a photodynamic therapeutic agent for the treatment and diagnosis of cancer.