Subphthalocyanine as a fluorescence imaging agent for breast tumor

YURT ONARAN F., Ince M., Er O., Soylu H. M., OCAKOĞLU K., YILMAZ O.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, cilt.26, ss.361-365, 2019 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.pdpdt.2019.04.022
  • Dergi Adı: PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.361-365
  • Anahtar Kelimeler: Subphthalocyanine, Fluorescence imaging, Mammary tumor, Nude mice
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Tri-tert-butyl-carboxyl subphthalocyanine (SubPc) was synthesized and evaluated as a fluorescence agent. Fluorescence imaging for breast tumor in vivo was performed using nude mice as models. Results indicate high uptake in tumor at 20 h. Tumor-non tumor ratio was determined as 2.25. The imaging results demonstrate the potential of this fluorescence-imaging agent in the diagnosis of breast tumor. In the future, subphthalocyanine is also developing as a dual functional, which is fluorescence imaging and as a photodynamic therapeutic agent for the treatment and diagnosis of cancer.