Insertion/Deletion polymorphism of the angiotensin I-converting enzyme gene in patients with breast cancer and effects on prognostic factors

Yaren A., Turgut S., Kursunluoglu R., Oztop I., Turgut G., Degirmencioglu S., ...More

JOURNAL OF INVESTIGATIVE MEDICINE, vol.55, no.5, pp.255-261, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 5
  • Publication Date: 2007
  • Doi Number: 10.2310/6650.2007.00006
  • Journal Name: JOURNAL OF INVESTIGATIVE MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.255-261
  • Keywords: angiotensin-converting enzyyme gene polymorphism, breast cancer, prognostic factors, TYPE-1 RECEPTOR, ACE GENE, CARCINOMA-CELLS, PROSTATE-CANCER, GASTRIC-CANCER, CHINESE WOMEN, GROWTH-FACTOR, TUMOR-GROWTH, RISK, INHIBITORS
  • Dokuz Eylül University Affiliated: Yes

Abstract

The aims of the present study were to investigate the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in breast cancer patients and the association between ACE genotypes and clinicopathologic features, as well as their effects on prognosis. We assessed the I/D polymophism of the ACE gene by using polymerase chain reaction from peripheral blood in breast cancer and healthy age-matched women. The clinicopathologic parameters of breast cancer patients were obtained from medical records. Of the 57 patients, 31 (54.4%) had DID, 24 (42.1%) had ID, and 2 (3.5%) had II genotypes. In control subjects, 33 (63.5%) had DD, 12 (23.1%) had ID, and 7 (13.4%) had II genotypes. The ID genotype was seen more commonly in breast cancer patients (p =.03). When the combination of ID and II genotypes was used as a reference group, the DD genotype was associated with negative hormone receptor status (p = .003), tumor size (p = .054), and lymph node involvement (p = .07) but not histologic high grade and c-erb B2 overexpression. These results suggest that the DID genotype may accompany poor prognostic factors and influence the tumor course.