Hashimoto's thyroiditis, but not treatment of hypothyroidism, is associated with altered TGF-beta1 levels.


AKINCI B., ÇÖMLEKÇİ A., Yener S., BAYRAKTAR F., DEMİR T., ÖZCAN M. A., ...More

Archives of medical research, vol.39, no.4, pp.397-401, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1016/j.arcmed.2007.12.001
  • Journal Name: Archives of medical research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.397-401
  • Keywords: thyroiditis, autoimmunity, cytokine, transforming growth factor beta, GROWTH-FACTOR-BETA, TRANSFORMING GROWTH-FACTOR-BETA-1, TGF-BETA, AUTOIMMUNE-THYROIDITIS, FOLLICULOGENESIS, EXPRESSION, CYTOKINE, FIBROSIS, CELLS, SERUM
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background. Although the role of cytokines in the development of Hashimoto's thyroiditis has already been established, its pathogenesis has not yet been clearly elucidated. The aim of our study was to investigate serum transforming growth factor-beta 1 (TGF-beta 1) levels in patients with Hashimoto's thyroiditis as well as the effect of achieving euthyroidism by levothyroxine replacement on TGF-beta 1 levels.