Statin pretreatment and risk of in-hospital atrial fibrillation among patients undergoing cardiac surgery: a collaborative meta-analysis of 11 randomized controlled trials


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Patti G., Bennett R., Seshasai S. R. K., Cannon C. P., Cavallari I., Chello M., ...More

EUROPACE, vol.17, no.6, pp.855-863, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.1093/europace/euv001
  • Journal Name: EUROPACE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.855-863
  • Keywords: Statins, Cardiac surgery, Postoperative atrial fibrillation, Meta-analysis, ENDOTHELIAL PROGENITOR CELLS, PREOPERATIVE STATINS, UPSTREAM THERAPIES, CLINICAL-EVIDENCE, CORONARY SURGERY, EUROPEAN-SOCIETY, BYPASS-SURGERY, DOUBLE-BLIND, TROPONIN-I, ATORVASTATIN
  • Dokuz Eylül University Affiliated: No

Abstract

Aims Statin pretreatment in patients undergoing cardiac surgery is understood to prevent postoperative atrial fibrillation (AF). However, this is based on observational and limited randomized trial evidence, resulting in uncertainty about any genuine anti-arrhythmic benefits of these agents in this setting. We therefore aimed to quantify precisely the association between statin pretreatment and postoperative AF among patients undergoing cardiac surgery.