Akademik Veri Yönetim Sistemi
JOURNAL OF CLINICAL ANESTHESIA, cilt.16, sa.7, ss.499-502, 2004 (SCI-Expanded, Scopus)
Study Objective: To compare the efficacy of alfentanil, remifentanil, and saline in minimizing the propofol injection pain. Design: Randomized, double-blind study. Setting: University hospital. Patients: 175 ASA physical status I and II, adult female patients undergoing minor gynecological procedures with general anesthesia. Interventions: Unpremedicated patients were randomly allocated to one Of four groups. Patients received 2 mL (1 mg) of alfentanil (n = 43), 2 mL of remifentanil 0.01 mg (n = 43), 2 mL of remifentanil 0.02 mg (n = 45), or 2 mL. of saline (n = 44) 30 seconds prior to administration 5 mL of propofol 1%. Measurements: Patients were asked whether they had pain due to propofol injection. Their pain scores were evaluated with a Visual Analogue Scale. In. the Postanesthesia Care Unit, frequency of postoperative nausea, vomiting, hypotension, and flushing were all determined. Main Result: The remifentanil and alfentanil groups showed significantly less frequency and severity of pain than the saline group (p < 0.05). When the alfentanil group was compared with the remifentanil groups, significant differences in pain relief associated with injection of propofol (p < 0.001) were noted. Remifentanil 0.02 mg relieved pain associated with injection of propofol more effectively than remifentanil 0.01 mg (p < 0.001). Conclusions: The remifentanil, and alfentanil groups showed significantly less frequency and severity of pain than did the saline g-roup. Remifentanil was effective in preventing propofol injection pain, and should be used at a dose of at least 0.02 mg for this purpose. Remifentanil may be an alternative drug for prevention of propofol injection pain. (C) 2004 by Elsevier Inc.