A case of severe thrombocytopenia developed due to cytomegalovirus and ganciclovir treatment in a healthy infant
Izmir Dr Behcet Uz Cocuk Hastanesi Dergisi, vol.6, no.3, pp.231-233, 2016 (ESCI, TRDizin)
- Publication Type: Article / Article
- Volume: 6 Issue: 3
- Publication Date: 2016
- Doi Number: 10.5222/buchd.2016.231
- Journal Name: Izmir Dr Behcet Uz Cocuk Hastanesi Dergisi
- Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Page Numbers: pp.231-233
- Keywords: Cytomegalovirus, healthy child, ganciclovir, thrombocytopenia
- Open Archive Collection: AVESIS Open Access Collection
- Dokuz Eylül University Affiliated: Yes
Abstract
Cytomegalovirus (CMV) infection is a common disease worldwide. While infection in immunocompetent individuals has traditionally been considered a benign and self-limited condition, a few studies have reported the clinical manifestations and treatment of CMV infection among immunocompetent patients. Ganciclovir treatment in children with cytomegalovirus infection is still controversial and it is used only in selected cases. We report here a case of a previously healthy 52-day-old girl who developed severe CMV disease with prolonged fever and profound thrombocytopenia. Short-term intravenous ganciclovir treatment was associated with immediate and sustained resolution of the symptoms as well as a sharp decrease of CMV viremia. Antiviral therapy should be considered in select cases of severe primary CMV infection in immunocompetent children.