Research Information System
EPNS Congress 2023: Prague, Praha, Czech Republic, 20 - 24 July 2023, pp.404-405
Objective: Reversible splenial lesion syndrome (RESLES) is a rare clinicoradyological entity characterized by a reversible lesion in
corpus callosum splenium. The reversible lesion in the splenium of corpus callosum is caused by various conditions. The common
associated conditions are seizures, antiepileptic drug withdrawal, infections, trauma, drug intoxication and metabolic
disturbances. Our study aims to describe clinical features, neuroimaging and laboratory findings of reversible splenial lesion
syndrome in children
Methods: Nine children aged 0-18 years who were diagnosed RESLES between 2011-2022 years were included in the study. We
retrospectively analyzed clinical course, etiology, magnetic resonance imaging (MRI), electroencephalography (EEG) findings and
prognosis.
Results: There were two boys and seven girls. The mean age was 10,25 ±5,2 years. The common neurological symptoms were
altered consciousness, visual complaints (blurred vision, transient blindness, diplopia), nausea and vomiting. Common associated
conditions were infection, seizure and head trauma. Rota virus (%33.3, n=2), Bartonella Hanselea (%16.6, n=1), Mcoplasma
Pneumonia (%16.6, n=1), Coronavirus OC43 (%16.6, n=1) were inciting infectious agents. All patients had typical radilolgical
features of RESLES. One patient was daignosed as mild encephalitis/encephalopathy with a reversible splenial lesion (MERS)
associated with Rota virüs infection. All patients in our study recovered clinically and radyologicaly without any sequelae.
Conclusions: RESLES etiology in children is various and has many clinical manifestations. The diagnosis of RESLES is mostly
based on neuroradiological imaging especially diffusion- weighed images. RESLES is an entity with a good prognosis and therefore
excessive treatment should be avoided.
Keywords:
RESLES, children, MERS, MRI