Fetal Inflammatory Response Syndrome and Brain Damage

KUMRAL A., Yesilirmak D. C.

GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS, cilt.5, sa.1, ss.25-27, 2007 (ESCI) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 5 Sayı: 1
  • Basım Tarihi: 2007
  • Dergi Adı: GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.25-27
  • Anahtar Kelimeler: Fetal inflammatory response syndrome, brain injury
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Intrauterine infection/inflammation has been identified as the most common cause of preterm delivery and neonatal complications. When microorganisms or their products gain access to the fetus they stimulate the production of cytokines and a systemic response termed FIRS (Fetal Inflammatory Response Syndrome). Subsequently, FIRS was implicated as a cause of fetal or neonatal brain injury that leads to cerebral palsy (CP). A relationship between CP and intra-amniotic inflammation was demonstrated, intrauterine infection may lead to activation of the cytokine network which in turn can cause white matter brain damage and preterm delivery, as well and as the future development of CP. This white matter insult is identified clinically as periventricular leucomalacia (PVL) which is associated with the subsequent development of impaired neurological outcomes of variable severity including CP.