Human beta defensin-1 and -2 expression in the gingiva of patients with specific periodontal diseases

Vardar-Sengul S., Demirci T., Sen B. H., Erkizan V., Kurulgan E., Baylas H.

JOURNAL OF PERIODONTAL RESEARCH, vol.42, no.5, pp.429-437, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 5
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1600-0765.2006.00964.x
  • Journal Name: JOURNAL OF PERIODONTAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.429-437
  • Keywords: defensin, gingiva, gingivitis, periodontitis, real-time polymerase chain reaction
  • Dokuz Eylül University Affiliated: No

Abstract

Background and Objective: beta defensin antimicrobial peptides are important in epithelial innate immunity, and their differential expression is associated with periodontal diseases. The aims of this study were to determine the mRNA expression of human beta defensin-1 and -2 in the gingival tissue of patients with gingivitis, aggressive periodontitis and chronic periodontitis, and to evaluate the relationship between defensin expression and type and/or severity of periodontal destruction.