Induction of Fetal Diuresis with Intraamniotic Furosemide Injection Reduces Intestinal Damage in a Rat Model of Gastroschisis

HAKGÜDER F. G., OLGUNER M., Gurel D., Akgur F. M., Flake A. W.

EUROPEAN JOURNAL OF PEDIATRIC SURGERY, vol.21, no.3, pp.183-187, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1055/s-0031-1271708
  • Journal Name: EUROPEAN JOURNAL OF PEDIATRIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.183-187
  • Keywords: gastroschisis, amniotic fluid, intestinal damage, intraamniotic furosemide injection, prenatal treatment
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background/Purpose: Contact with amniotic fluid causes intestinal damage (ID) in fetuses with gastroschisis. Intraamniotic meconium has been shown to be responsible for ID, and ID has been shown to correlate with intraamniotic meconium concentrations. ID can be prevented by lowering the intraamniotic meconium concentration. A new method to lower intraamniotic meconium concentration might consist in the induction of fetal diuresis with intraamniotic diuretic injection. This hypothesis was tested in a rat model.