Induction of Fetal Diuresis with Intraamniotic Furosemide Injection Reduces Intestinal Damage in a Rat Model of Gastroschisis

HAKGÜDER F. G., OLGUNER M., Gurel D., Akgur F. M., Flake A. W.

EUROPEAN JOURNAL OF PEDIATRIC SURGERY, cilt.21, sa.3, ss.183-187, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1055/s-0031-1271708
  • Dergi Adı: EUROPEAN JOURNAL OF PEDIATRIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.183-187
  • Anahtar Kelimeler: gastroschisis, amniotic fluid, intestinal damage, intraamniotic furosemide injection, prenatal treatment, ALLANTOIC FLUID EXCHANGE, URINARY TRYPSIN-INHIBITOR, HUMAN NEONATAL URINE, AMNIOTIC-FLUID, TRANSABDOMINAL AMNIOINFUSION, SEVERE OLIGOHYDRAMNIOS, MECONIUM, BOWEL, PREVENTION, THERAPY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background/Purpose: Contact with amniotic fluid causes intestinal damage (ID) in fetuses with gastroschisis. Intraamniotic meconium has been shown to be responsible for ID, and ID has been shown to correlate with intraamniotic meconium concentrations. ID can be prevented by lowering the intraamniotic meconium concentration. A new method to lower intraamniotic meconium concentration might consist in the induction of fetal diuresis with intraamniotic diuretic injection. This hypothesis was tested in a rat model.