Research Information System
Asia Pacific Association for the Study of the Liver annual Congress, Kyoto, Japan, 27 - 31 March 2024, vol.18, no.344, pp.564-565, (Summary Text)
Fib-4 and Fatty Liver Indices in Low- and High-Risk Prediabetes by Anthropometric Categorization
Prediabetes, characterized by elevated blood glucose levels not meeting diabetes criteria, requires monitoring to prevent diabetes and its complications. This population is diverse, with individuals categorized as low or high-risk for cardiovascular issues based on anthropometric indices.Objective: We aimed to explore if low-risk and high-risk prediabetes patients, as defined by anthropometric indices, also differ in fatty liver index (FLI) and Fib4 scores.Methods: Our study encompassed various prediabetes subgroups as shown below, totaling 657 patients, analyzed via waist to hip ratio (WHR), body mass index (BMI), visceral adiposity index (VAI), lipid accumulation products (LAP), body shape index (BSI), body roundness index (BRI), conicity index (CI) values. The isolated impaired fasting glucose (IFG) and isolated elevated HbA1c (HbA1c) groups, showcasing consistently lower anthropometric scores, were deemed low-risk, while other subgroups (impaired glucose tolerance (IGT), IFG?IGT, IFG?HbA1c, IGT?HbA1c, IFG?IGT?HbA1c) were labeled high-risk. Beyond numerous parameters, we calculated and tested differences in Fib4 and FLI values between these groups, employing the C statistic for discriminative cut-off values identification.Results: Fib4 median values were 0.762 (95%CI: 0.683-0.789) and 0.886 (95%CI: 0.826-0.961), FLI were 55.77 (95%CI: 48.79-61.99) and 72.89 (95%CI: 67.12-76.02) in low- and high-risk prediabetes (p\0.0001) respectively. Fib4 cut-off was [0.9425 (sensitivity 46.4%, specificity 71.8%; AUC: 0.601; p\0.0001), FLI cut-off was 70.20 (sensitivity 53.5%, specificity 67.5%; AUC: 0.622; p\0.0001).Conclusions: Significant differences in FLI and Fib4 values exist between low- and high-risk prediabetics, although their discriminative power is limited. High-risk individuals, according to anthropometric indices, warrant closer monitoring for liver complications.