A computer software for simulating single-compartmental model of neurons

Ozer M., Isler Y., Ozer H.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, cilt.75, sa.1, ss.51-57, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 75 Sayı: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.cmpb.2003.08.002
  • Dergi Adı: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.51-57
  • Anahtar Kelimeler: simulation, neuronal modeling, computer software, voltage-gated ion channels, excitable membranes, MICROSOFT EXCEL
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

In this paper, a new computer software package, Yalzer, is introduced for simulating single-compartmental model of neurons. Passive or excitable membranes with voltage-gated ion channels can be modeled, and current clamp and voltage clamp experiments can be simulated. In the Yalzer, first-order differential equations used to define the dynamics of the gate variables and the membrane potential are solved by two separate integration methods with variable time steps: forward Euler and exponential Euler methods. Outputs of the simulation are shown on a spreadsheet template for allowing flexible data manipulation and can be graphically displayed. The user can define the model in detail, and examine the excitability of the model and the dynamics of voltage-gated ion channels. The software package addresses to ones who want to run simple simulations of neurons without need to any programming language skills or expensive software. It can also be used for educational purposes. (C) 2003 Elsevier Ireland Ltd. All rights reserved.