Plasma Homocysteine Levels in Patients with Pseudoexfoliation


ÖZTÜRK A. T., ARIKAN G., Kuralay F., GÜNENÇ Ü.

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.31, no.5, pp.1204-1210, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.5336/medsci.2010-21924
  • Journal Name: TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1204-1210
  • Keywords: Hyperhomocysteinemia, exfoliation syndrome, glaucoma, RETINAL VEIN OCCLUSION, OPEN-ANGLE GLAUCOMA, ATHEROSCLEROTIC RISK-FACTORS, ISCHEMIC OPTIC NEUROPATHY, EXFOLIATION SYNDROME, AQUEOUS-HUMOR, ENDOTHELIAL FUNCTION, OXIDATIVE STRESS, VASCULAR-DISEASE, HYPERHOMOCYSTINEMIA
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: To evaluate plasma homocysteine (Hcy) levels in patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, primary open angle glaucoma and healthy control subjects. Material and Methods: Twenty patients with primary open angle glaucoma (POAG), twenty patients with pseudoexfoliation (PEX) glaucoma, twenty patients with PEX syndrome and twenty control subjects were enrolled. Mean plasma Hcy levels of four groups were determined using high-performance-liquid-chromatography and were compared. Then all participants were classified into two groups as subjects with or without PEX and were compared. Patients who had any history of a systemic disease known to be associated with high plasma Hcy levels and taking vitamin B supplements within the previous year were excluded. Results: Of the 80 patients, 43 were females (53.75%) and 37 were males (46.25%). Mean age was 69.11 +/- 8.53 years. Mean plasma Hcy levels were 19.02 +/- 10.66 mu mol/l, 19.13 +/- 17.76 mu mol/l, 10.58 +/- 3.50 mu mol/l and 9.92 +/- 2.59 mu mol/l in patients with PEX syndrome, PEX glaucoma, POAG and control subjects, respectively. Hcy levels in patients with PEX glaucoma were significantly higher when compared to POAG patients and the control group (p=0.025, p=0.004, respectively). Hcy levels in patients with PEX syndrome were also significantly higher when compared to POAG patients and the control group (p=0.001, p=0.000, respectively). Hcy levels in patients with POAG were not statistically different from the control group (p=0.365). When the patients were classified into two groups as subjects with or without PEX, mean plasma Hcy levels were found as 19.08 +/- 14.44 mu mol/l and 10.25 +/- 3.06 mu mol/l, respectively (p=0.000). Conclusion: Hcy levels were found to be significantly higher in PEX with or without glaucoma.