Effects of exercise and poor indoor air quality on learning, memory and blood IGF-1 in adolescent mice


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Uysal Harzadın N., Kiray M., Sisman A., Baykara B., Aksu İ., Dayı A., ...More

BIOTECHNIC & HISTOCHEMISTRY, vol.89, no.2, pp.126-135, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 89 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.3109/10520295.2013.825318
  • Journal Name: BIOTECHNIC & HISTOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.126-135
  • Keywords: adolescent, air quality, carbon dioxide, exercise, hippocampus, IGF-1, learning, memory, prefrontal cortex, MATERNAL-DEPRIVATION, HIPPOCAMPAL DAMAGE, PREFRONTAL CORTEX, NEURON DENSITY, IMMATURE RATS, BRAIN, INJURY, DYSFUNCTION, EXPRESSION, APOPTOSIS
  • Dokuz Eylül University Affiliated: Yes

Abstract

It is known that regular aerobic exercise enhances cognitive functions and increases blood insulin-like growth factor 1 (IGF-1) levels. People living in urban areas spend most of their time indoors and indoor air quality can affect health. We investigated the effects of aerobic exercise in poor and good air quality environments on hippocampus and prefrontal cortex (PFC) neurons, anxiety, and spatial learning and memory in adolescent mice. Poor air quality impaired spatial learning and memory; exercise did not affect learning or memory impairment. Exercise in a good air quality environment improved spatial learning and memory. Poor air quality increased apoptosis in the hippocampus and PFC. Both exercised and sedentary groups living in a poor air quality environment had lower serum IGF-1 levels than those living in a good air quality environment. Living in a poor air quality environment has negative effects on the hippocampus, PFC and blood IGF-1 levels in adolescent mice, but exercise did not alter the negative effects of poor air quality.