Chronic Graft Dysfunction and Improvement by Cytokine Response Modifier a Protein Transfection

Xiao Z., Shan J., Li C., Luo L., Feng L., Lu J., ...More

EXPERIMENTAL AND CLINICAL TRANSPLANTATION, vol.9, no.5, pp.302-309, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 5
  • Publication Date: 2011
  • Journal Name: EXPERIMENTAL AND CLINICAL TRANSPLANTATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.302-309
  • Keywords: CrmA gene, Cyclosporine, Chronic graft dysfunction, HK-2 cell lines, Chronic cyclosporine nephropathy, CHRONIC CYCLOSPORINE NEPHROTOXICITY, A-INDUCED APOPTOSIS, MITOCHONDRIAL DYSFUNCTION, TRANSPLANT PATIENTS, RENAL INJURY, EXPRESSION, CRMA, CELLS, MECHANISMS, OVEREXPRESSION
  • Dokuz Eylül University Affiliated: No

Abstract

Objectives: Cytokine response modifier A protein is a caspase inhibitor that inhibits caspase activity and protects cells from apoptosis. Chronic cyclosporine nephropathy is a significant cause of chronic graft dysfunction. We explored cytokine response modifier A protein-alleviated chronic cyclosporine nephropathy for ways of improving chronic graft dysfunction.