The city of Izmir constitute many big scale hospital buildings, which constructed between 17th century and 19th century by minorities; and modernist health facilities of Republic period and also productions that has different architectural styles of the period of after 1980. There is not any comprehensive study about health facilities of the city and also about the spatial and architectural characteristics of them. In this paper, the hospital buildings of the period of before Republic are researched but predicated buildings that constructed really as a hospital on except transformed buildings. In consideration of the detailed literature review, it is aimed to introduce the notion of health in Izmir and its spatial reflections in Izmir, to document extant or absent hospitals and to criticize the spatial development of hospitals in the city. The hospitals were generally belonged to minorities and reflected the Western architectural trends of foreigner architects in the period of pre-Republic. However, neo-classic style, which was widespread in public buildings of Ottoman architecture, was seen in hospitals of Izmir.