The Effect of Plasminogen Activator Inhibitor-1-675 4G/5G Polymorphism on Familial Mediterranean Fever (FMF) Disease

Demiralp D. O., Ekim M., Akar N.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, vol.15, no.4, pp.443-447, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 4
  • Publication Date: 2009
  • Doi Number: 10.1177/1076029608325540
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.443-447
  • Keywords: plasminogen activator-1, familial Mediterranean fever, amyloidosis, atherosclerosis, ACUTE-PHASE RESPONSE, SERUM AMYLOID-A, VASCULAR RISK, INFLAMMATION, GENE, ATHEROSCLEROSIS, DIAGNOSIS, MORTALITY, PROTEIN, OBESITY
  • Dokuz Eylül University Affiliated: No


Familial Mediterranean fever (FMF) is an autosomal recessive disease that is the most common of a rare group of disorders collectively termed familial hereditary periodic fever syndromes, also known as autoinflammatory syndromes. FMF is predominantly affecting people of Mediterranean descent and clinically characterized by intermittent attacks of fever with peritonitis and abdominal pain, pleuritis, arthritis, or erysipelas-like rashes. Amyloidosis due to chronic inflammation progressing to renal failure is one of the most serious potential complications of this disease.