Research Information System
TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.32, no.1, pp.39-46, 2012 (SCI-Expanded)
Objective: In this study, hemodynamic effects of levosimendan (L) on dexmedetomidine (D) infusion in rats were investigated under isoflurane (I) anesthesia. Material and Methods: A total of eighteen female Wistar-Albino rats were divided into 3 groups. Rats were artificially respirated following cannulation and tracheostomy. At the end of the stabilization period (15 min), initial hemodynamic values were recorded and (i) 1(1.4%) was administered to Group I; (ii) 1(1.4%) and D (1 mu g/kg/dk) were administered to Group ID and (iii) 1 (1.4%), D (1 mu g/kg/dk) and L (0.3 mu g/kg/dk) were administered to Group IDL for 60 min. Heart rate (HR)(bpm), systolic (SAP), diastolic (DAP) and mean arterial pressure (MAP) (mmHg) were recorded with 5 min intervals were and given as mean and/or %. One way variance analysis, Tukey-Kramer and paired t tests were used, p<0.05 was considered the level of significance. Results: No difference was found between groups in terms of initial hemodynamic values. On the contrary, significant differences were found in HR (p=0.03) and DAP (p=0.03) at the end of the infusion period between groups. The differences were correlated to the lower HR in Group ID (176) compared to Group 1(237), (p<0.05) and a higher DAP in Group IDL (67) compared to Group 1(48), (p<0.05). In in-group comparisons; SAP (80 vs. 71 [90%], p=0.03), DAP (59 vs. 48 [81%] p=0.049), MAP (69 vs. 57 [83%], p=0.03) decreased significantly in Group I and HR (206 vs. 176 [85%], p=0.008) decreased significantly in Group ID at the end of the infusion period when compared to baseline values. Conclusion: In rats, I led to a decrease in systemic arterial pressure; and Din the presence of I led to a decrease in HR. Isoflurane-related systemic arterial pressure decrease was prevented by using of D and combination of D and L. Additionally, D-related HR decrease in the presence of I was prevented by using L. In this study, positive effects of D and DL utilization were observed when systemic arterial pressure dropped due to I. Besides, positive effect of L utilization was observed when HR decreased due to D in the presence of I in rats.