Effects of oxcarbazepine treatment on serum lipids and carotid intima media thickness in children

YİŞ U., Dogan M.

BRAIN & DEVELOPMENT, cilt.34, sa.3, ss.185-188, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.braindev.2011.05.009
  • Dergi Adı: BRAIN & DEVELOPMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.185-188
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

The aim of this study is to evaluate the carotid Ultima media thickness and serum lipids in pediatric patients with epilepsy treated with oxcarbazepine. The study included 21 pediatric epileptic and 22 healthy children. Intima media thickness and fasting lipid profile were assessed. Although the median value of total cholesterol was in normal limits in the oxcarbazepine group, it was significantly higher when compared with the control group. We did not observe any differences regarding triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and carotid intima media thickness. We suggest that oxcarbazepine treatment in children has a minor effect on serum lipids and it does not seem to have an atherogenic effect. (C) 2011 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.