Diagnostic and Prognostic Molecular Features of Urothelial Bladder Cancer and New Treatment Approaches


Kucukodaci Z., YÖRÜKOĞLU K.

UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY, vol.14, no.4, pp.258-270, 2015 (ESCI) identifier

  • Publication Type: Article / Review
  • Volume: 14 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.4274/uob.366
  • Journal Name: UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.258-270
  • Keywords: Biomarkers, bladder cancer, personalized medicine, targeted therapy, urothelial cancer
  • Dokuz Eylül University Affiliated: Yes

Abstract

As a result of improvement of the knowledge about cancer genetics and genomics, substantial developments have occurred in the clinical management of cancers. Molecular diagnosis and therapies targeted at altered genetic pathways are important stages of breast, colon, lung and other cancers. However, this progress is not effective in urologic malignancies as well. Recent studies suggest that Her2, epidermal growth factor receptor, fibroblast growth factor receptor, mTOR and others may have clinical benefits in urinary bladder cancers. In this article, recent developments in molecular pathogenesis of bladder cancer, prognostic significance of molecular mechanisms, molecular tumor markers, and the role of molecular biomarkers reviewed.