Akademik Veri Yönetim Sistemi
Turkish Journal of Medical Sciences, cilt.23, sa.1, ss.31-35, 1995 (SCI-Expanded)
Whole bowel irrigation (WBI) has been reported to be a safe and effective method of gastrointestinal decontamination for acute overdoses. This technique could be of potential benefit in those situations in which cathartics may best be avoided (e.g., renal failure, overload states, etc). In this study we investigated the effectiveness of WBI with PEG-ELS (polyethylene glycol electrolyte lavage solution) or magnesium sulphate (MgSO4) vs. control after acute iron overdose in a rabbit model. Three groups of rabbits received a single PO dose of elemental iron (200 mg/kg) via orogastric tube. While 8 rabbits were used as control, 7 rabbits were started to be administered PEG-ELS orally one-half hour after iron ingestion and this was continued for 6 hours. Another 7 rabbits received a single dose of MgSO4 orally one-half hour after iron ingestion. Serum iron levels, electrolytes, and arterial blood gases were measured over a period of 24 hours. In this rabbit model, PEG-ELS did not induce diarrhea, and using WBI with this solution resulted in a serum-iron AUC (Area under the curve) that was the same as the control. A single dose of MgS04 decreased the AUC by approximately half but resulted in a more severe metabolic acidosis than the control and PEG-ELS groups. SGPT was significantly increased at the 24th hour in the control and PEG-ELS groups. This animal model is not suitable for demonstrating the effectiveness of WBI in acute overdoses. Other animal models need to be developed for investigation of WBI in iron overdose.