The effects of gender on grey matter abnormalities in major psychoses: a comparative voxelwise meta-analysis of schizophrenia and bipolar disorder

BORA İ. E., Fornito A., Yuecel M., Pantelis C.

PSYCHOLOGICAL MEDICINE, cilt.42, sa.2, ss.295-307, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1017/s0033291711001450
  • Dergi Adı: PSYCHOLOGICAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.295-307
  • Anahtar Kelimeler: Bipolar disorder, grey matter, MRI, schizophrenia, voxel based morphometry, GRAY-MATTER, WHITE-MATTER, 1ST-EPISODE SCHIZOPHRENIA, BRAIN GRAY, STRUCTURAL ABNORMALITIES, AUDITORY HALLUCINATIONS, COGNITIVE DEFICITS, VOLUME DIFFERENCES, MORPHOMETRY, REDUCTION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background. Recent evidence from genetic and familial studies revitalized the debate concerning the validity of the distinction between schizophrenia and bipolar disorder. Comparing brain imaging findings is an important avenue to examine similarities and differences and, therefore, the validity of the distinction between these conditions. However, in contrast to bipolar disorder, most patient samples in studies of schizophrenia are predominantly male. This a limiting factor for comparing schizophrenia and bipolar disorder since male gender is associated with more severe neurodevelopmental abnormalities, negative symptoms and cognitive deficits in schizophrenia.