Progressive increase of glucose transporter-3 (GLUT-3) expression in estrogen-induced breast carcinogenesis

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Kocdor M. A., Kocdor H., Pereira J. S., Vanegas J. E., Russo I. H., Russo J.

CLINICAL & TRANSLATIONAL ONCOLOGY, vol.15, no.1, pp.55-64, 2013 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 15 Issue: 1
• Publication Date: 2013
• Doi Number: 10.1007/s12094-012-0882-3
• Journal Name: CLINICAL & TRANSLATIONAL ONCOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.55-64
• Keywords: GLUT, Estrogen, Breast, Cancer
• Open Archive Collection: AVESIS Open Access Collection
• Dokuz Eylül University Affiliated: Yes

Abstract

Increased glucose uptake and glycolysis are main metabolic characteristics of malignant cells. A family of glucose transporters (GLUTs) facilitates glucose movement across the plasma membranes in a tumor-specific manner. Glucose transporter-1 (GLUT-1), GLUT-3 and recently GLUT-12, have been previously shown in breast cancer cells and are found to be associated with poor prognosis. In addition, it has been shown that estrogen plays critical roles in GLUT regulation, however, the stage-specific GLUT regulation of mammary carcinogenesis is unclear.