Progressive increase of glucose transporter-3 (GLUT-3) expression in estrogen-induced breast carcinogenesis

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Kocdor M. A., Kocdor H., Pereira J. S., Vanegas J. E., Russo I. H., Russo J.

CLINICAL & TRANSLATIONAL ONCOLOGY, cilt.15, sa.1, ss.55-64, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s12094-012-0882-3
  • Dergi Adı: CLINICAL & TRANSLATIONAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.55-64
  • Anahtar Kelimeler: GLUT, Estrogen, Breast, Cancer, HYPOXIA-INDUCIBLE FACTOR-1-ALPHA, GROWTH-FACTOR RECEPTOR, GLYCOLYTIC PHENOTYPE, SIGNALING PATHWAY, MAMMARY-GLAND, MESSENGER-RNA, HUMAN CANCER, CELL, GLUCOSE-TRANSPORTER-1, ACID
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Increased glucose uptake and glycolysis are main metabolic characteristics of malignant cells. A family of glucose transporters (GLUTs) facilitates glucose movement across the plasma membranes in a tumor-specific manner. Glucose transporter-1 (GLUT-1), GLUT-3 and recently GLUT-12, have been previously shown in breast cancer cells and are found to be associated with poor prognosis. In addition, it has been shown that estrogen plays critical roles in GLUT regulation, however, the stage-specific GLUT regulation of mammary carcinogenesis is unclear.