Prophylaxis effects of water kefir on post-infectious irritable bowel syndrome in rat model

Gokirmakli C., EROL Z., Gun I., Ozmen O., SEYDİM Z. B.

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, vol.58, no.6, pp.3371-3378, 2023 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 6
  • Publication Date: 2023
  • Doi Number: 10.1111/ijfs.16310
  • Journal Name: INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Compendex, Food Science & Technology Abstracts, INSPEC, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Page Numbers: pp.3371-3378
  • Keywords: Irritable bowel syndrome, lactic acid bacteria, pathology, prophylaxis, water kefir
  • Dokuz Eylül University Affiliated: No

Abstract

Water kefir (WK) is produced using WK grains containing beneficial bacteria and yeasts. It has antibacterial, anti-inflammatory, anti-diabetic, anti-hyperlipidaemic, anti-ulcerogenic, and antioxidant effects. The purpose of the research was to determine the effect of WK on irritable bowel syndrome (IBS). In this study, thirty-two female Wistar-Albino rats aged 3 months were randomly distributed to four groups: the control group (C), the WK group, the WK group with IBS (WK + IBS), and the IBS group. Results indicated that the IBS groups had higher white blood cell, lymphocyte, monocyte counts, and procalcitonin levels. The findings of WK + IBS group showed that WK improved against IBS. TNF-alpha, NF-kB expressions, and histopathological results significantly decreased after receiving WK treatment. In conclusion, ingestion of WK has prophylactic effects on IBS as exhibited through an in-vivo murine model. The findings suggested that IBS may be prevented and treated with WK.