Regulatory T Cells and Their Prognostic Value in Hepatopancreatobiliary Tumours

Ozgur H. H., ERÇETİN A. P., Eliyatkin N., Seren A., Kupelioglu A., Ortac R., ...Daha Fazla

HEPATO-GASTROENTEROLOGY, cilt.61, sa.135, ss.1847-1851, 2014 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 135
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5754/hge14619
  • Dergi Adı: HEPATO-GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.1847-1851
  • Anahtar Kelimeler: Treg cells, CD4 CD8 T cells, gallbladder cancer, pancreatic cancer, liver cancer, PROGRESSION, CANCER, FOXP3
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background/Aims: The aim of this study was to determine the prognostic values of Foxp3+ Treg cells, CD4+ Tcells and CD8+ T cells in cancer cases of gallbladder, pancreas and liver. Methodology: This study included 20 patients with gallbladder cancer, 25 patients with pancreatic cancer and 8 patients with liver cancer. Foxp3, CD4 and CD8 were immunohistochemically evaluated and compared with histopathological and clinical prognostic parameters. Results: Foxp3, CD4 and CD8 expression levels were significantly higher in peritumoral areas than in intratumoral areas in patients with gallbladder, pancreas, liver cancers (p<0,05). Positivity of Foxp3, CD4 and CD8 was correlated with advanced stage (p<0,05), poor differentiation, lymphovascular invasion, perineural invasion, advanced age. Patients with high positivity of Foxp3 had a shorter disease free survival (p<0,05). Conclusion: Our results indicate that the ratio of Tregs/T helper cells (Foxp3+/CD4+) cells was higher in intratumoral area in hepatopancreatobiliary tumors. We conclude that intratumoral inlamatory cells might work for cancer cells, besides peritumoral cells work against cancer cells.