COMPARATIVE PROGNOSTIC PERFORMANCE OF ALBUMIN, PROCALCITONIN, AND LACTATE FOR IN HOSPITAL MORTALITY IN OLDER EMERGENCY DEPARTMENT PATIENTS WITH URINARY TRACT INFECTION

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Köse Ş.

INTERNATIONAL CONFERENCE ON GLOBAL PRACTICE OF MULTIDICIPLINARY SCIENTIFIC STUDIES - III , Tbilisi, Gürcistan, 5 - 06 Ekim 2026, cilt.1, sa.1, ss.242-243, (Tam Metin Bildiri)

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası: 1
  • Basıldığı Şehir: Tbilisi
  • Basıldığı Ülke: Gürcistan
  • Sayfa Sayıları: ss.242-243
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

ABSTRACT Objective: Urinary tract infections (UTIs) are common among older adults and may be associated with substantial morbidity and mortality. Although procalcitonin and lactate are widely used as markers of infection severity and systemic illness, serum albumin may also reflect inflammatory burden and reduced physiological reserve in older patients. This study aimed to compare the prognostic performance of albumin, procalcitonin, and lactate for in-hospital mortality in older emergency department patients with UTI. Methods: This retrospective cohort included 129 older adults diagnosed with UTI in the emergency department. In-hospital mortality was the primary outcome. Admission albumin, procalcitonin, and lactate levels were compared between survivors and non-survivors. Normally distributed variables were compared using the independent-samples t-test, whereas non-normally distributed variables were analyzed using the Mann–Whitney U test. Discriminative performance for in-hospital mortality was assessed using receiver operating characteristic (ROC) analysis, and areas under the curve (AUCs) were compared using paired-sample ROC analysis. Results: Thirty-five patients (27.1%) died during hospitalization. Albumin levels were significantly lower among non-survivors than survivors (3.04±0.50 vs 3.38±0.62, p=0.004). Lactate [2.80 (IQR 1.60) vs 1.90 (IQR 0.80)] and procalcitonin [5.31 (IQR 5.16) vs 1.85 (IQR 1.15)] were significantly higher among non survivors (both p<0.001). Procalcitonin showed the highest discrimination for mortality (AUC 0.849, 95% CI 0.754–0.945), followed by lactate (AUC 0.799, 95% CI 0.716–0.882) and albumin (AUC 0.666, 95% CI 0.566–0.766). Albumin performed significantly worse than both lactate (p=0.039) and procalcitonin (p=0.011), whereas the difference between procalcitonin and lactate was not significant (p=0.392). Conclusion: Procalcitonin and lactate demonstrated good discriminatory performance for in-hospital mortality in older patients with UTI. Although hypoalbuminemia was significantly associated with mortality,