Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome

Temur M., Yilmaz O., Aksun S., Ozbay P. O., Calan M., KÜME T., ...More

GYNECOLOGICAL ENDOCRINOLOGY, vol.32, no.3, pp.218-222, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.3109/09513590.2015.1110135
  • Journal Name: GYNECOLOGICAL ENDOCRINOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.218-222
  • Keywords: PCOS, urocortin-3, hs-CRP, insulin, BETA-CELL FUNCTION, INSULIN-RESISTANCE, GLUCOSE-INTOLERANCE, OXIDATIVE STRESS, WOMEN, DYSFUNCTION, INFLAMMATION, PARAMETERS, RECEPTOR, OBESITY
  • Dokuz Eylül University Affiliated: Yes

Abstract

This study was aimed to compare serum urocortin-3 (UCN3) levels in women with polycystic ovary syndrome (PCOS) and healthy women, and establish what role UCN3 levels play in PCOS. Fifty-two patients with PCOS and 55 healthy women were included in the study, matched for age and body mass index. Fasting blood glucose (FBG), insulin, hs-CRP, UCN3 and free-testosterone levels of the all participants were measured. HOMA-IR was used to calculate the insulin resistance. Circulating UCN3 levels were significantly increased in women with PCOS than in control subjects (54.49 +/- 5.77 versus 51.28 +/- 5.86 pmol/l, p = 0.005). Serum insulin, hs-CRP and HOMA-IR levels were higher in women with PCOS than in control group. UCN3 levels positively correlated with hs-CRP in PCOS group (r = 0.391, p = 0.004). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curves were 0.732 (95% CI 0.634-0.830, p < 0.001) for UCN3 levels. The optimal cut-off value of UCN3 for detecting PCOS was >= 51.46 pmol/l, at which the sensitivity was 75% and specificity was 68%. Our results suggest that there is a potential link between PCOS and UCN3 levels. The results of this study support the presence of increased UCN3 levels for the association of inflammation with PCOS.