Production of wheat germ oil containing multilayer hydrogel dressing

TÜRKOĞLU G. C., Sariisik M., KARAVANA S. Y., Koseme F. A.

CARBOHYDRATE POLYMERS, vol.269, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 269
  • Publication Date: 2021
  • Doi Number: 10.1016/j.carbpol.2021.118287
  • Journal Name: CARBOHYDRATE POLYMERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: Sodium alginate, Wheat germ oil, Soft hydrogel, Wound dressing, WOUND DRESSINGS, DRUG-DELIVERY, WATER-VAPOR, ALGINATE, COMPOSITE, CHITOSAN, MEMBRANES, SILVER, MICROENCAPSULATION, ANTIBACTERIAL
  • Dokuz Eylül University Affiliated: Yes

Abstract

A composite wound dressing has been developed by combining different layers consisting of polymers and textiles. Wheat germ oil (WGO) loaded hydrogels have successfully formed on textile nonwovens by cross-linking sodium alginate (SA) with poly(ethylene glycol) diglycidyl ether (PEGDGE). Following freeze-drying, textilehydrogel composites have been examined according to their physical properties, pH, fluid handling capacity, water vapour permeability, morphology, chemical structure, and cytotoxicity. Hydrogels containing WGO swelled less than pristine hydrogels. Samples with 1% WGO and no WGO showed swelling of 5.9 and 10.5 g/g after 8 h. WGO inclusion resulted in reduced, but more stable fluid handling properties, with more uniform pore distribution (100-200 mu m). Moreover, the proliferation of NIH/3T3 cells significantly improved with 1% WGO contained hydrogels. Also, commercial self-adhesive dressings that secure the hydrogels to the wound area were investigated regarding transfer properties. The proposed product demonstrated 8.05 cm3/cm2/s and 541.37 g/ m2/day air and water vapour permeability.