A COMPARISON OF DIGOXIN CONCENTRATION - TIME CURVES BEFORE AND AFTER OPEN-HEART-SURGERY

ACIKEL U., GUVEN H., APAYDIN S., SILISTRELI E. E., GIDENER S., CATALYUREK H. H., ...Daha Fazla

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.21, sa.3, ss.147-153, 1993 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 3
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1177/030006059302100305
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.147-153
  • Anahtar Kelimeler: DIGOXIN, CARDIAC GLUCOSIDES, OPEN-HEART SURGERY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The effects of open heart surgery on serum digoxin concentration - time curves were investigated in 10 cardiac patients receiving 0.25 mg/day digoxin. Blood samples were obtained from the patients immediately before and 1, 2, 3, 5, 8, 16 and 24 h after digoxin administration, both before open-heart surgery and 7 days after surgery. Serum digoxin concentrations, determined by fluorescence polarization immuno-assay, significantly (P < 0.05) increased after surgery, as did the maximum serum concentrations and the areas under the concentration - time curves. After surgery there was a significant increase in the serum gamma-glutamyl transferase concentration and a significant reduction in the total protein concentration. A reduction of digoxin dose may be appropriate for patients who have undergone open-heart surgery.