Helicobacter pylori infection and phagocytosis

DEMİRAY GÜRBÜZ E., Bekmen N.

MIKROBIYOLOJI BULTENI, vol.42, no.1, pp.177-184, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 1
  • Publication Date: 2008
  • Journal Name: MIKROBIYOLOJI BULTENI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.177-184
  • Keywords: Helicobacter pylori, macrophage, neutrophil, phagocytosis, PROFESSIONAL PHAGOCYTES, HUMAN NEUTROPHILS, MACROPHAGES, PERSISTENCE, ACTIVATION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Helicobacter pylori is a chronic infectious agent defined as the major pathogen causing gastritis, gastric and duodenal ulcer, gastric carcinoma and mucosa associated lenfoid tissue (MALT) lymphoma. H.pylori is the only microorganism known to get colonized in human stomach and inhabit in gastric mucosal cells. To achieve this, H.pylori must escape from both innate and adaptive immune responses. The host immune response is unable to eliminate the infection and this is generally associated with pathogenesis. The persistence of the induced H.pylori infection suggests that the response is not effective to eliminate the infection., In this review article, the correlation between H.pylori infection and innate immune response with emphasis on the avoidance of killing by phagocytosis, have been discussed.