Akademik Veri Yönetim Sistemi
International Multidisciplinary Symposium on Drug Research and Development (DRD) 2023, İzmir, Türkiye, 4 - 06 Mayıs 2023, ss.1
In vitro organ-on-a-chip (OoC) platforms can host and maturate stem cell derived engineered human tissues. Such platforms provide novel research venues for life sciences by mimicking the native tissue architecture, biophysical environment and functionality. Such tools facilitate investigation of cellular mechanotransduction, tissue morphogenesis and advanced control of other physiological factors affecting in vitro performance of organoids. Advances in stem cell research enable the in vitro recapitulation of human organogenesis and let the generation of functional tissue models called organoids. Today, combination of on-chip microfluidic systems with stem cell technologies creates many organ models such as lung, gut, brain, liver, kidney and stomach, which can be connected to form human-on-a-chip systems. Translation of these platforms to clinical settings promises effective disease models, test beds for toxicology and diagnosis. As growing interest of pharma industry on bioengineered OoCs, organoid models drug screening become more attractive. This talk covers fundamental aspects of on-chip system design and integration with stem cell research.
ACKNOWLEDGEMENT:
The author has been supported by TÜBİTAK projects 117S264 and 121C313, TÜBA-GEBİP and BAGEP awards.