The value of serum acetylcholinesterase level for clinical and mortality in patients with organophosphate toxicitiy

Kahraman N., Çolak N., Kalkan Ş., Hocaoğlu Aksay N., Uğurhan A., Yanturalı S.

EuSEM 2008, 5th European Congress on Emergency Medicine, 3rd Annual Meeting of the DGINA, Munich, Almanya, 15 - 18 Eylül 2008, cilt.15, sa.1, ss.295-296, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Cilt numarası: 15
  • Doi Numarası: 10.1097/mej.0b013e32830f9732
  • Basıldığı Şehir: Munich
  • Basıldığı Ülke: Almanya
  • Sayfa Sayıları: ss.295-296
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objectives The aim of study is to evaluate the relationship between the serum acetylcholinesterase (AChE) level and the clinical course and mortality in patients who presented to the university hospital emergency department with organophosphate and carbamate toxicity between June 1993 and June 2007. Methods All patients who presented to the hospital emergency department with organophosphate and carbamate toxicity between June 1993 and June 2007 were included in this retrospective analytic study. Demographic characteristics, type of toxic agent, route and reason for the exposure, clinical signs and findings, serum AChE levels, mechanical ventilation requirements, complications that developed and outcome of the patients were analyzed. Results A total of 108 patients were included in this study. The mean age was 34.1 ± 18.6 and the male/female ratio was 1.57. The mean serum AChE level was 3167 ± 3503 IU/l. (31–13685 IU/l) The mean serum AChE level in the patients who required mechanical ventilation was significantly lower according to the patients who did not (1103.90 ± 1718.92, 3843.55 ± 3680.44 IU/l, P < 0.01, respectively). The leading cause of complication was pneumonia which was detected in 12 patients. The mean serum AChE level in the patients who developed complications was significantly lower according to the patients who did not (735.66 ± 985.81, 3589.95 ± 3613.61 IU/l, P < 0.01, respectively). In this study 6 of our patients have died (%5.6). The mean serum AChE level of the patients who died was significantly lower according to the survival group (637.50 ± 502.55, 3369.46 ± 3562.56 IU/l, P < 0.01, respectively). Conclusion Our results indicate that lower serum AChE levels are associated with higher risk of in-hospital mortality and complicated clinical course in organophosphate and carbamate toxicity. The serum AChE level may be used as a valuable parameter in risk assessment in organophosphate and carbamate intoxication.