Akademik Veri Yönetim Sistemi
14th International Gastrointestinal Cancers Conference (IGICC2024), İstanbul, Türkiye, 28 Kasım - 01 Aralık 2024, sa.9, ss.12-13, (Tam Metin Bildiri)
Objectives: This study aims to assess the prognostic significance of pre-treatment biomarkers before their initial treatment with gastric cancer. Materials-Methods: The study retrospectively examined all regardless of metastasis at diagnosis or a history of second cancer, over the age of 18 male and female patients diagnosed with gastric cancer and treated at the Medical Oncology Clinic of Dokuz Eylül University between 2010 and 2021. The study included 335 patients whose pre-treatment complete blood count and biochemical parameters were recorded in the hospital’s information management system. Results: The demographic, clinical, pathological, hematological, and biochemical parameters of the patients were examined. The study examined the association between SIRI, PIV, NLR, SII, PNI, RDW/Albumin Ratio, LNR and LODDS scores, formulated with parameters adhering to the literature, and patients’ OS and DFS duration. According to the results of multivariate Cox regression analysis, in patients diagnosed with locally advanced gastric cancer, SIRI > 1.45 and PNI < 0.48, and in patients diagnosed with metastatic gastric cancer, SSII > 823.0 were found to be the most significant risk factors for mortality. In locally advanced gastric cancer patients who underwent surgery, LNR and LODDS were found to be determinative factors in both DFS duration and the risk of recurrence. Conclusion: In the literature, there is no study that comprehensively evaluates such a diverse set of parameters together and demonstrates significant findings for many of them. Keywords: Gastric Cancer, Overall Survival, Disease Free Survival